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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Curr Opin Neurobiol. 2014 Apr 22;0:171–178. doi: 10.1016/j.conb.2014.03.016

Figure 1.

Figure 1

CSPGs mediate the distinct migratory behaviors of turning and addiction. (A) Extending axons and migrating neuroblasts are re-directed, or “turned” away from developmentally-regulated proteoglycan boundaries when their receptor profiles favor adhesion to the non-addictive ECM molecules (i.e. laminin and fibronectin) adjacent to these CSPG-rich barriers. (B) In contrast, migrating neuroblasts and extending axons may become “addicted” to moving within CSPG-rich tracts through preferential expression of CSPG-receptors.