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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Ophthalmology. 2014 Apr 16;121(8):1495–1500.e1. doi: 10.1016/j.ophtha.2014.03.004

Table 1.

Natamycin and voriconazole minimum inhibitory concentration (MIC) by treatment arm


Organism		 Natamycin (µg/ml) Voriconazole (µg/ml)
No. MIC50
(95%
CI)b 		MIC90a
(95%
CI) b 		MIC
Range		 No. MIC50
(95%
CI)b 		MIC90a
(95%
CI)b 		MIC
Range
Fusarium species 60 4 (4 to 4) 8 (4 to 8) 2–32 66 4 (2 to 4) 8 (8 to 16) 0.5–16
Aspergillus species 25 32 (8 to 32) 64 (64 to 64) 2–64 27 0.5 (0.5 to 1) 2 (1 to 4) 0.25–4
A. flavus 14 32 (32 to 64) 64 (32 to 64) 8–64 18 0.5 (0.5 to 1) 2 (1 to 4) 0.25–4
A. fumigatus 5 4 ND 2–64 5 0.5 ND 0.25–4
A. niger 2 5 ND 2–8 0 NA NA NA
A. terreus 3 16 ND 8–16 0 NA NA NA
Other Aspergillus species 1 2 ND 2 4 0.5 ND 0.5–2
Curvularia species 9 2 (2 to 2) 2 (2 to 2) 1–2 8 0.38 ND 0.25–2
Exserohilum species 2 1.5 ND 1–2 6 1 ND 0.5–2
Alternaria species 2 2 ND 2–2 0 NA NA NA
Bipolaris species 3 2 ND 2–2 1 1 ND 1
Lasiodiplodia species 2 2 ND 2–2 1 0.5 ND 0.5
Other species 1 2 ND 2 1 0.5 ND 0.5
Unidentified dematiaceous 1 4 ND 4 2 1.12 ND 0.25–2
Unidentified hyaline 3 4 ND 4–8 1 0.03 ND 0.03
Total (N=221) 108 4 (4 to 4) 32 (16 to 64) 1–64 113 2 (1 to 2) 8 (4 to 8) 0.03–16
P-value <0.001c <0.001c

Abbreviations: No., number; MIC50, minimum inhibitory concentration median; MIC90, minimum inhibitory concentration 90th percentile; CI, confidence interval; NA, not available; ND, not determined

a

MIC90 was estimated for genus or species with at least 9 observations, the smallest number where extrapolation would not be necessary.

b

95% CIs for MIC50 and MIC90 were estimated as bootstrap percentile confidence intervals for genus or species with at least 9 observations.

c

Analysis of variance test comparing MICs among genera