Table 4.
Proportion successfully treated with natamycin or voriconazole, by minimum inhibitory concentration
| Organism | Treatment arm |
Total No. |
MIC (µg/ml) |
Cases with Successful Treatment, % (No. of Cases/ Total No. of Cases)a |
|---|---|---|---|---|
| Fusarium species | Natamycin | 60 | 2 | 100 (6/6) |
| 4 | 91 (42/46) | |||
| 8 | 83 (5/6) | |||
| 16 | 100 (1/1) | |||
| 32 | 100 (1/1) | |||
| Voriconazole | 66 | 0.5 | 0 (0/3) | |
| 1 | 40 (2/5) | |||
| 2 | 50 (10/20) | |||
| 4 | 75 (18/24) | |||
| 8 | 60 (6/10) | |||
| 16 | 75 (3/4) | |||
| Aspergillus flavus | Natamycin | 14 | 8 | 100 (1/1) |
| 32 | 50 (4/8) | |||
| 64 | 40 (2/5) | |||
| Voriconazole | 18 | 0.25 | 50 (2/4) | |
| 0.5 | 100 (7/7) | |||
| 1 | 0 (0/4) | |||
| 2 | 0 (0/2) | |||
| 4 | 100 (1/1) | |||
Abbreviations: MIC, minimum inhibitory concentration; No., number
a
Success defined as improvement in visual acuity from baseline AND no corneal perforation and/or therapeutic penetrating keratoplasty