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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Mol Genet Metab. 2014 Jun 6;112(4):286–293. doi: 10.1016/j.ymgme.2014.05.015

Figure 5.

Figure 5

A: Full-thickness view of knee cartilage, treated with saline for six months (Storage score: 3). The sample is oriented with articular surface to the upper left, and the deep zone to the lower right. Higher-power views of the articular surface and deep zone demonstrate chondrocytes filled with foamy storage material.

B: Full-thickness view of knee cartilage, treated with rhIDUA for six months (Storage score: 1). The sample is oriented like A, with higher-power views of articular surface and deep zone. Chondrocytes both at the surface and deep zone demonstrate more cytoplasm and much less storage than saline-treated chondrocytes.

C: Knee cartilage from a similarly aged, wild-type dog for reference.