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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Pharmacogenet Genomics. 2014 Sep;24(9):464–476. doi: 10.1097/FPC.0000000000000058

Figure 2. Potential mechanisms underlying allopurinol-induced SCARs.

Figure 2

graphic file with name nihms595093u2.jpg

Dashed arrows represent hypothesized mechanisms of action that may underly allopurinol-induced severe cutaneous adverse reactions (SCARs) linked to the HLA-B*5801 allele (see main text for further description).

HLA = human leukocyte antigen

MHC = major histocompatibility complex

TCR = T cell receptor