Table 2.
Characteristics of REDD1 WT and KO mice fed a low- or high-fat diet
| WT-LF | WT-HF | KO-LF | KO-HF | |
|---|---|---|---|---|
| Body weight, g | 33.7 ± 1.4 | 44.1 ± 1.8* | 41.7 ± 1.6* | 46.4 ± 1.9* |
| Plantar flexor complex, g | 0.16 ± 0.01 | 0.17 ± 0.01 | 0.16 ± 0.0.01 | 0.17 ± 0.01 |
| Liver, g | 1.3 ± 0.1 | 1.5 ± 0.1* | 1.3 ± 0.1 | 1.7 ± 0.1* |
| eWAT, g | 1.1 ± 0.1 | 2.3 ± 0.1* | 1.7 ± 0.1* | 2.0 ± 0.2* |
| Food intake | ||||
| g/day | 3.5 ± 0.1 | 3.2 ± 0.1 | 3.3 ± 0.1 | 2.9 ± 0.1* |
| kcal/day | 13.4 ± 0.4 | 16.8 ± 0.5‡ | 12.5 ± 0.4 | 15.3 ± 0.5‡ |
| Total kcal | 790.8 ± 20.9 | 989.2 ± 29.7‡ | 740.3 ± 25.7 | 902.7 ± 29.4‡ |
| Glucose, mg/dl | 82.8 ± 33.0 | 266.5 ± 16.9* | 112.8 ± 32.0 | 229.2 ± 13.1*† |
| Insulin, μIU/ml | 2.71 ± 0.02 | 4.28 ± 0.69* | 2.98 ± 0.10 | 5.27 ± 1.47* |
| HOMA-IR | 0.55 ± 0.22 | 2.85 ± 0.63* | 0.84 ± 0.25 | 3.59 ± 0.66* |
| NEFA, mmol/l | 0.85 ± 0.05 | 1.07 ± 0.16* | 0.73 ± 0.04 | 0.58 ± 0.08* |
Values are means ± SE. WT and KO are REDD1 wild type and knockout, respectively; LF, low-fat diet; HF, high-fat diet.
*
Statistically different from WT-LF (P < 0.05).
‡
Statistically different from the LF group (P < 0.05).
†
Significantly different from WT-HF (P < 0.05).