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HO-1 mediates the suppression of LPS-induced NO production in RAW 264.7 cells. Cells were pre-incubated with 200 µg/ml ECM for 30 min before exposure 30 µM ZnPP and LPS (1 µg/ml) for 24 h. The treated culture media were used to measure the amount of nitrite production. Each value is expressed as a mean ± standard error (n = 3). #P < 0.05 compared to LPS, *P < 0.05 compared to LPS + ECM.
