Fig. 4.

4-AP decreases spike pattern diversity in mitral cells. A and B: spike responses in the control condition (A, top left) and in the presence of 4-AP (B, top left) to a 2-s frozen noise stimulus projected onto the space defined by the first 2 PCs. Each point is a trial, each color corresponds to a single mitral cell. A and B: distribution of responses in the 2 conditions along PC1 (bottom left) and PC2 (top left) with the decrease in the SD along both PC1 (A, bottom right) and PC2 (B, bottom right) illustrating the decrease in spike pattern diversity. Mean distance of spike trains from pairs of neurons within a single animal and between 2 different animals in the control condition (C) and following the addition of 4-AP (D). 4-AP reduces the diversity of spike train responses in a single animal (E) and across pairs of neurons from different animals (F).