Fig. 2.
DHP site L-type calcium channel (LTCC) blocker nifedipine decreases basal firing rates in WT and Cav1.2DHP−/− mice. A: current-clamp recording from representative cells showing firing rates in control, with nifedipine (5 μM for 10 min), and after nifedipine was washed out for 6 min in control, WT, and Cav1.2DHP−/− mice. B: changes in firing frequencies after nifedipine (5 μM) in control, WT, and Cav1.2DHP−/− mice. C: % changes in firing rate reductions with or without nifedipine (5 or 10 μM for 10 min) in WT and Cav1.2DHP−/− mice. *P < 0.05.