Table 1.
Basic electrophysiological properties of dopaminergic cells in wild type (WT), Cav1.2DHP−/− and Cav1.3−/− mice
| wild type (WT)1 | Cav1.2DHP−/−2 | Cav1.3−/−3 | P1,2 | P1,3 | |
|---|---|---|---|---|---|
| Number of spontaneously active cells | 18 of 31, 58.1% | 32 of 50, 64.0% | 7 of 26, 26.9% | >0.05 | <0.05 |
| Resting membrane potentials (mV) | −52.69 ± 1.17 | −51.98 ± 1.03 | −52.13 ± 1.18 | >0.05 | >0.05 |
| Basal firing frequencies (Hz) | 0.68 ± 0.20 | 0.72 ± 0.11 | 0.25 ± 0.07 | >0.05 | <0.05 |
| Spike amplitude (mV) | 58.00 ± 2.39 | 58.13 ± 2.09 | 54.62 ± 2.31 | >0.05 | >0.05 |
| Firing threshold (mV) | −38.91 ± 0.76 | −38.87 ± 0.88 | −41.03 ± 1.71 | >0.05 | >0.05 |
| Spike half-width (ms) | 2.97 ± 0.11 | 3.01 ± 0.15 | 2.97 ± 0.20 | >0.05 | >0.05 |
| Hyperpolarizing afterpotentials (mV) | −13.20 ± 1.57 | −13.57 ± 1.30 | −13.81 ± 1.51 | >0.05 | >0.05 |
| Hyperpolarization following an application of 50 μM dopamine (mV) | −9.01 ± 1.02 | −9.46 ± 1.00 | −7.96 ± 1.07 | >0.05 | >0.05 |
| Ih sag (mV) | 20.98 ± 1.17 | 20.09 ± 1.10 | 19.20 ± 1.00 | >0.05 | >0.05 |
Values are means ± SE.