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. 2014 Jul 21;15:90. doi: 10.1186/1471-2202-15-90

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© Rockenstein et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Comparison of effects of aging on p-Tau in non-tg single tg and Tau/GSK3β bigenic mice. (A) Representative images of immunohistochemical analysis with the p-Tau (AT8) in the neocortex and hippocampus in the non-tg, single tg and Tau/GSK3β bigenic mice at 3, 6 and 12 months of age. (B) Image analysis of optical density in the hippocampus represented as a line graph in the non-tg, single tg and Tau/GSK3β bigenic mice at 3, 6 and 12 months of age. Scale bar = 250 μm, in lower panels = 250 μm. Error bars represent mean ± SEM (n = 6 per age and genotype).