Table 6.

dN/dS ratios for various OR protein domains

Family D	Entire molecule
32 genes	0.44±0.10	TM1	0.28±0.18	IN1	0.36±0.33
		TM2	0.24±0.23	IN2	0.69±0.72
		TM3	0.64±0.46	IN3	0.26±0.26
		TM4	0.83±1.01	OUT1	0.22±0.22
		TM5	0.58±0.39	OUT2	1.14±1.06
		TM6	0.42±0.41	OUT3	0.80±0.56
		TM7	0.36±0.35
Family E	Entire molecule
56 genes	0.40±0.11	TM1	0.57±0.27	IN1	0.24±0.01
		TM2	0.52±0.48	IN2	0.42±0.37
		TM3	0.73±0.79	IN3	0.32±0.37
		TM4	0.69±0.39	OUT1	0.43±0.24
		TM5	0.70±0.44	OUT2	0.30±0.23
		TM6	0.23±0.21	OUT3	0.41±0.38
		TM7	0.21±0.12
Family H	Entire molecule
50 genes	0.41±0.13	TM1	0.56±0.47	IN1	0.35±0.24
		TM2	0.24±0.22	IN2	0.23±0.15
		TM3	0.48±0.43	IN3	0.34±0.24
		TM4	0.53±0.39	OUT1	0.39±0.51
		TM5	0.76±0.68	OUT2	0.64±0.36
		TM6	0.84±0.51	OUT3	0.67±0.72
		TM7	0.27±0.29
Family L	Entire molecule
32 genes	0.50±0.12	TM1	0.56±0.42	IN1	0.23±0.11
		TM2	0.59±0.58	IN2	0.41±0.38
		TM3	0.76±0.43	IN3	0.59±0.33
		TM4	1.48±1.54	OUT1	0.29±0.34
		TM5	0.63±0.36	OUT2	0.35±0.22
		TM6	0.72±0.42	OUT3	0.40±0.34
		TM7	0.56±0.58
Family N	Entire molecule
32 genes	0.39±0.14	TM1	0.45±0.35	IN1	0.57±0.35
		TM2	0.79±0.37	IN2	0.60±0.55
		TM3	0.68±0.57	IN3	0.41±0.33
		TM4	0.95±0.54	OUT1	0.35±0.27
		TM5	0.56±0.41	OUT2	0.24±0.11
		TM6	0.60±0.41	OUT3	0.40±0.13
		TM7	1.20±1.07

dN/dS ratios for the 7 TM regions, and the 3 external and 3 internal loops for the 4 largest families were calculated. TM regions and loops were identified with PolyPhobius.