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. 2014 Jul 28;14:266. doi: 10.1186/1472-6882-14-266

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© de Faveri Favero et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Antinociceptive activity of Lac-FR related to chemical neurogenic pain stimulus. First phase (0–5 min) for reactivity time to the intraplantar application of formalin (formaldehyde 1.2% in PBS) in the hind paw of mice previously treated i.p. (30 min) with control vehicle (10 ml/kg i.p.) morphine (10 mg/kg i.p.) indomethacin (10 mg/kg i.p.) or fraction (30, 100, and 300 mg/kg i.p.). Results expressed as mean ± S.E.M. of 6 animals for experimental groups (ANOVA and Tukey’s test. ***p < 0.001, **p < 0.01).