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The antinociceptive effects of Lac-FR against thermal stimulus. Effect of the Lac-FR on tail flick test. Mice were treated i.p. with Lac-FR (30, 100 and 300 mg/kg i.p.), morphine (5 mg/kg i.p.), and vehicle (10 ml/kg i.p.), 0.5 h before evaluation. Evaluation times were 0.5, 1, 2, 4 and 24 hs. (ANOVA and Bonferroni’s test. ***p < 0.001).
