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. 2014 Jul 28;14:266. doi: 10.1186/1472-6882-14-266

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© de Faveri Favero et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Evidences of the involvement of opioid system in the antinociception caused by Lac-FR. The antinociceptive effect increase of morphine (5 mg/kg i.p.), morphine (5 mg/kg i.p.) associated with naloxone (5 mg/kg s.c.), and Lac-FR (100 mg/kg i.p.) associated with naloxone (5 mg/kg s.c.), after one hour period were 70.21% (morphine), 21.94% (morphine with naloxone), 16.62% (Lac-FR with naloxone), and 46.96% (Lac-FR 100 mg/kg i.p.), respectively. Evaluation times were 0.5, 1, 2, 4, and 24 hs. (ANOVA and Bonferroni’s test. ***p < 0.001, **p < 0.01, *p < 0.05).