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. 2014 Aug 6;34(32):10488–10496. doi: 10.1523/JNEUROSCI.1406-14.2014

Figure 4.

Figure 4.

Glucoprivic stimuli evoke increases in gastric motility that can be blocked by fourth ventricular application of FC in the anesthetized rat. Plots on the left are gastric strain gauge recordings taken before any experimental manipulation. Plots on the right represent strain gauge recordings 1 h after the application of a stimulus. A, 4V 2DG causes a significant increase in gastric motility. B, FC, an astrocyte-specific metabolic inhibitor, applied to the 4V before 2DG (4V FC+2DG) blocks the 2DG effect. C, FC applied to the 4V (4V FC) alone has no effect on basal gastric motility pattern. D, Subcutaneous insulin produces a dramatic increase in gastric motility (Insulin, s.c.). E, 4V FC largely blocks the effects of insulin to increase gastric motility (4V FC + Insulin s.c.). These data suggest that astrocytes in the hindbrain detect glucoprivic conditions and can activate vagal pro-motility circuits.