Figure 9.

cAMP signaling pathway was involved in the change of temporal precision of AP firing of neurons in the ACC in vitro. A, CFA injection did not change the temporal precision of APs firing in the ACC of AC1 KO mice. B, Bath application of forskolin increased the slope of jitter in normal mice, blocking of the activities of both excitatory and inhibitory receptors abolished the increase. C, Activating of the cAMP signaling pathway by forskolin application increased the jitter of APs, which depends on the synaptic transmission.