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. 2014 Aug 6;34(32):10765–10769. doi: 10.1523/JNEUROSCI.5316-13.2014

Figure 2.

Figure 2.

In vivo Nav1.8 antisense treatment reduces TTX-resistant Na+ current and SA in small primary afferent neurons tested in vitro after SCI. A, Reduction of TTX-resistant current 18–24 h after Nav1.8 ASO injection. Depolarizing steps evoked smaller currents compared with MMO treatment (left and middle). Peak TTX-resistant current was significantly reduced ∼20 h, but not ∼40 h, after the last ASO injection (right). B, ASO treatment decreased the incidence of SA (example in left) 3 d and 1–2 months after SCI (right). Significant suppression from lumbar Nav1.8 ASO injection occurred in lumbar, but not thoracic (T8, T9, T11, T12), DRG neurons.