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. 2014 Aug 6;4:5970. doi: 10.1038/srep05970

Figure 3. Effects of KUSs on ATPase activities, ATP levels, and acetyl-CoA levels.

Figure 3

(a) Inhibition of ATPase activity in clarified whole cell lysates by KUS121, KUS187, and KUS94, but not KUS11. Total ATPase activities in clarified whole cell lysates from differentiated PC12 cells were measured in the absence and presence of KUSs. Relative ATPase activities are shown with values in the absence of KUS (D: DMSO) set at 100%. (b) HeLa cells were cultured in medium with low glucose (0.25 g/l) for 20 hours, with or without KUSs, and ATP levels were measured with luciferase assays. (c) HeLa cells were cultured in medium with low glucose (0.25 g/l) for 20 hours, with or without KUSs, and acetyl-CoA levels were measured. * P < 0.05, ** P < 0.01, *** P < 0.001 vs. DMSO control (Dunnett's test, n = 3).