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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: J Pediatr Surg. 2014 May 16;49(8):1286–1291. doi: 10.1016/j.jpedsurg.2014.04.001

Figure 5.

Figure 5

Macrophage infiltration was decreased in JTE-013-treated NB xenografts. (A and B) Quantitative real-time PCR was performed in NB xenografts treated with or without S1P2 antagonist JTE-013 to detect the mRNA expression of CCL2 (A) and murine F4/80 (B). Data was normalized to that of the housekeeping gene GAPDH and presented as means ± SE. (C) Immunohistochemistry staining was performed to detect the F4/80 positive cells in control and JTE-013-treated NB xenografts and photos were taken under the light microcrope (20x). A representative picture from each group (left) and the quantitative result (right) were shown. *, P < 0.05, **, P < 0.01 versus the corresponding control.