Table 3.
Changes relative to baseline measurements (performed 10–30 days before the first exposure) for parameters measured in sputum [GM % (95% CI), n = 16].
| Variable | 0 ppb NO2 (clean air) | 200 ppb NO2 | 600 ppb NO2 | pTrend |
|---|---|---|---|---|
| Percentage of eosinophils | –12 (–34, 16) | –5 (–28, 26) | 57 (18, 109)** | 0.04 |
| Day 1 | 16 (–28, 86) | –34 (–59, 6) | 12 (–31, 79) | 0.81 |
| Day 2 | –5 (–37, 44) | –3 (–36, 46) | 102 (32, 211)** | 0.01 |
| Day 3 | –39 (–67, 13) | 36 (–26, 149) | 79 (–3, 230) | 0.03 |
| No. of eosinophils/mg | –5 (–31, 29) | 23 (–10, 68) | 120 (60, 202)# | 0.02 |
| Day 1 | –5 (–44, 60) | –24 (–55, 29) | 64 (–3, 177) | 0.10 |
| Day 2 | 9 (–39, 95) | 23 (–31, 119) | 142 (32, 344)** | 0.06 |
| Day 3 | –18 (–57, 56) | 99 (5, 278)* | 163 (38, 398)** | 0.03 |
| ECP | 21 (–1, 47) | 0 (–18, 22) | 43 (17, 75)** | 0.23 |
| No. of neutrophils/mg | 12 (–17, 51) | –9 (–32, 22) | 10 (–19, 49) | 0.97 |
| No. of macrophages/mg | –18 (–33, 0) | –2 (–20, 21) | –6 (–24, 15) | 0.46 |
| GM percentages represent all changes of the parameter for the 3 days (one sputum induction per day). *p < 0.05; **p < 0.01; and #p < 0.001, compared with baseline. | ||||