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. 2014 Jul 17;5(7):e1324. doi: 10.1038/cddis.2014.283

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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CMS genes associated with ES cell differentiation. (a) Gene clustering showing the gene expression profiles of CMS genes during retinotic acid (RA)-induced differentiation in human ES cells. Only genes with twofold or greater change in at least one time point during differentiation are shown. Self-renewing factors, OCT4, SOX2 and NANOG2, were included in this analysis as experimental control. The genes were rank ordered in terms of fold-changes. In total, 40 CMS genes were found to be associated with differentiation and 68 genes were found to be associated with self-renewal. Hand1 was ranked ordered as top CMS gene associated with differentiation. (b) Listed are 21 PRC2 target genes previously identified in ES cells