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. 2014 Jul 17;5(7):e1324. doi: 10.1038/cddis.2014.283

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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Pharmacological reactivation of HAND1 in colon cancer cells. (a) qRT-PCR analysis showing the expression of HAND1 and SFRP1 mRNA in HCT116 and DKO cells treated with 5 μM DZNep, 100 nM TSA or their combination. (b) ChIP-PCR showing the changes of EZH2, H3K27me3 and H3K4me3 in HCT116 and DKO cells with or without DZNep plus TSA treatment. (c and d) qRT-PCR analysis of HAND1 mRNA expression in HCT116 and DLD1 cells following the indicated drug treatments. (e) qRT-PCR analysis of HAND1 mRNA expression in SW480 cells following the indicated drug treatments. (f) ChIP-PCR analysis indicated the changes of H3K4me3 and H3K27me3 in SW480 cells with or without DZNep plus TSA treatment. Error bars indicate±S.D.