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. 2014 Jul 17;5(7):e1324. doi: 10.1038/cddis.2014.283

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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HAND1 is silenced in multiple human cancers. (a) Expression profiles of 40 differentiation-related CMS genes in human colorectal tumors and matched normal mucosa. Genes are rank ordered in terms of fold expression between tumor and normal samples. (b) RT-PCR analysis of HAND1 expression from eight randomly selected pairs of human colorectal tumor (T) and matched mucosa (N). β-Actin was used as PCR control. (c) MSP analysis of HAND1 promoter in eight selected tumors. (d) Bisulfite sequencing of HAND1 promoter from normal colon epithelium and tumor. (e) HAND1 is significantly suppressed in multiple-type of cancer. Representative data are shown across multiple independently published microarray studies as indicated. P-values are shown below