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. 2014 Jul 17;5(7):e1336. doi: 10.1038/cddis.2014.285

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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Targeted metabolomics reveals significant alterations of glycolytic intermediates, glucose-derived non-essential amino acids, free carnitine, and AcCs, suggesting increased lactic fermentation and inhibition of FAoxidation in BCSCs. Bar graphs show the mean concentrations of (a) glycolytic and Krebs cycle intermediates and (b) amino acids and free carnitine in BCSCs and SDACs. Results of targeted metabolomic analysis are available in the Supplementary Table S5. The differences shown in the bar graphs are all significant (two-tailed t-test, P<0.050). Concentrations are expressed as ng/mg (wet weight). Bars show the mean value±S.D. (n=6)