Table 2. Autophagy-modulating miRNAs with relevance to CVD.

miRNAs	Relevance to CVD	Targets relevant to autophagy	Function	Refs
miR-30	Downregulated in a model of cardiac hypertrophy and by angiotensin II	BECN1	Vesicle nucleation	192
	Circulating miR-30 elevated in patients with left-ventricular hypertrophy
miR-204	Reduces cardiomyocytes autophagy in response to hypoxia-reoxygenation			193, 194
	Concomitant downregulation of miR-204 and induction of autophagy following cardiac ischemia-reperfusion in rats	MAP1LC3A	Vesicle maturation and fusion with the lysosome	195
	Downregulated in pulmonary arterial smooth muscle cells from patients with PAH
miRNA-212/132	Impaired autophagy in starved cardiomyocytes	FOXO3 PTEN	Pro-autophagic transcription factor	196
	Induced cardiac hypertrophy
miR-21	Cell treatment with anti-miR-21 induced autophagy	BECN1 MAP1LC3A PIK3C3 (VPS34)		197
	Not yet investigated with regards to cardiomyocte autophagy