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. 2014 Jul 17;5(7):e1342. doi: 10.1038/cddis.2014.310

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/

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A-T post-mitotic cells are resistant to CPT and trabectedin treatment. Neurons at D30 grown in 96-well plates were assessed for cell viability by CellTiter-Glo 72 h after exposure to H₂O₂ for 20 min (a), or continuously with Paraquat (b), CPT (c) and trabectedin (d) at the indicated doses. All treatments were performed in triplicate wells. The graphs show mean±S.D. and, where indicated, the difference between Ctrl and A-T was statistically significant (*P<0.05; ^#P<0.01) (analysis performed by the Student's t-test)