Table 1.

miRNA regulation in diverse regions of the somatosensory nociceptive pathway in different chronic pain conditions

miRNA studieda	Pain model	Tissue studied	Time point studied	Observed expression change	Refs
miRNAs in peripheral nervous system
Neuropathic pain
miRNA-183 cluster (comprising miR-183, miR-182, and miR-96)	SNL in mice	DRGs	14 days	Decreased	[10]
	SNC in mice	Sciatic nerves	4 and 7 days following SNI	Decreased	[79]
miRNA-183	SNL in rat	DRGs	7 and 14 days	Decreased	[15]
miRNA-21	SNT in rat	DRGs	7 days	Increased	[60]
	SNR in rat	DRGs	4 days	Increased	[80]
	SNC in mice	Sciatic nerves	4 and 7 days	Increased	[79]
miR-7a	SNL in rat	Ipsilateral lumbar 5 (L5) DRGs	14 days	Decreased	[58]
miR-96	CCI in rat	Ipsilateral DRG	Day 7–21	Decreased	[62]
miR-143	SNT in mice	Ipsilateral DRG	6 days	Decreased	[16]
miR-1, miR-16, miR-206	SNA in mice	Ipsilateral DRG	Day 1–3	Increased	[18]
miR-125b-5p, miR-30d-5p, miR-379-5p	SNL in rats genetically segregated to sense high or low neuropathic pain	Ipsilateral DRG	3 days	Differentially regulated	[81]
Inflammatory pain
miR-183, miR-124a	CFA-induced inflammatory muscle pain model in rat	Ipsilateral trigeminal ganglion	4 h to 4 days	Decreased	[82]
miR-134	CFA-induced inflammatory pain model in rat	Ipsilateral DRGs	Days 1–14	Decreased from 1 to 7 days and increased at 14 days	[83]
miR-183 cluster, miR-146a	Knee-joint osteoarthritis (OA) model in rat	Ipsilateral lumbar DRGs and SDH	2, 4, and 8 weeks	Decreased	[84,85]
miR-143	CFA model in mice	Ipsilateral DRGs	2 days	Decreased	[16]
miR-1, miR-16, miR-206	CFA model in mice	Ipsilateral DRGs	12 h to 7 days	Decreased	[18]
Cancer-associated pain
miR-1a-3p, miR-544-3p, miR-34c-5p, and 23 other miRNAs	Bone metastasis model in mouse	Ipsilateral DRGs	8 days	Increased	[9]
miR-370-3p, miR-483-3p, miR-291b-5p, and 28 other miRNAs	Bone metastasis model in mouse	Ipsilateral DRGs	8 days	Decreased	[9]
miRNAs in spinal cord
miR-137, miR-181a, miR-219-2-3p, and 247 other miRNAs	Traumatic SCI in rat	SDH	4 h and 1 and 7 days	Differential regulation	[86]
miRNA-203	Bilateral CCI in rat	SDH	14 days	Decreased	[87]
miR-103	SNL in rat	SDH	Not available	Decreased	[34]
miR-1	SNA in mice	SDH	Days 1–3	Decreased	[18]
miR-1, miR-124, miR-129-1, miR-129-2	SCI in rat	Whole spinal cord	4 and 14 days	Decreased	[88]
miR-223	SCI in mice	Whole spinal cord	6 h to 7 days	Increased from 6 h to day 3	[89]
miR-124a	SCI in mice	Whole spinal cord	6 h to 7 days	Decreased from day 1 to 7	[89]
miR-21	SCI in mice	Whole spinal cord	Days 4–35	Increased at day 35	[90]
miR-146a	OA in rat	Lumbar SDH	2 and 4 weeks	Decreased	[84]
miR-124a	Intraplantar application of formalin or interleukin-1β (IL-1β) (an inflammatory mediator) in mice	SDH or in spinal microglia	Hours 1–48	Decreased from 1 to 24 h, basal levels at 48 h	[35,57]
miR-1, miR-16, miR-206	CFA in mice	SDH	Days 1–7	Increased	[18]
miRNAs in brain regions involved in pain
miR-155, miR-223	Model of facial inflammatory pain in mouse	Prefrontal cortex	Day 3	Increased	[23]
miR-200b, miR-429	PNL model of neuropathic pain in mice	Nucleus accumbens	Day 7 after sciatic nerve ligation was found	Decreased	[24]
miR-146a, miR-34c, miR-125b-5p, miR-1, and others	CCI in rat	Hippocampus	Days 7 and 14	Decreased	[91]
let-7 family members, miR-103, and others	CCI in rat	Hippocampus	Days 7 and 14	Increased	[91]

Abbreviations: SNL, spinal nerve ligation; SNC, sciatic nerve crush; SNI, spared nerve injury; SNT, sciatic nerve transaction; SNR, sciatic nerve resection; CCI, chronic constriction injury; SNA, sciatic nerve axotomy; DRG, dorsal root ganglion; OA, osteoarthritis; CFA, Freund's Complete Adjuvant; SCI, spinal cord contusion injury; PNL, partial nerve ligation.

^aFor genome-wide expression studies, only miRNAs that were confirmed with an independent method are listed.