Table 1.

Baseline Characteristics of Controls and TP53 Mutation Carriers.^*

Variable	Controls (N = 20)	Carriers (N = 20)	P Value
Age (yr)	40±15	38±13	0.57
Female sex (%)	55	60	1.00
Body-mass index†	26.9±4.2	27.2±5.3	0.83
Physical-activity level‡	3.1±1.2	3.3±1.2	0.59
Weight lifted in foot exercise (kg)§	3.4±1.2	3.3±1.5	0.88

^*Plus–minus values are means ±SD. The control group consisted of 9 healthy volunteers and 11 members of families with the Li–Fraumeni syndrome who were not carriers of the TP53 mutation.

^†Body-mass index is the weight in kilograms divided by the square of the height in meters.

^‡Physical-activity level was self-rated by each study participant and ranged from 1 (inactive, with no regular physical activity) to 5 (vigorously active, with physical activity at least 4 days a week for 60 minutes or more each time).

^§The weight lifted represented 30% of the maximum weight against which a participant could dorsiflex one foot before testing.