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Kaplan-Meier curves for microvascular outcome Neph-4 (doubling of serum creatinine or more than 20 mL/min/1.73m2 decrease in estimated GFR) by glycemia arm. Panel A: data until transition of intensive glycemia arm to standard therapy. Panel B: all data through end of study. Hazard ratios adjusted for baseline history of clinical cardiovascular disease and second trial treatment arm assignment.
