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. 2014 Jul 15;24(8):977–993. doi: 10.1038/cr.2014.94

Figure 1.

Figure 1

Endogenous Tom70 is decreased in pathological hypertrophic myocardium of humans and experimental animals. (A) The expression of Tom complex genes in human cardiac tissues (n = 5 per heart failure (HF); n = 3 per non-failing control (NF)). (B) Echocardiographic analysis of heart weight/body weight (HW/BW), left ventricular posterior wall thickness (LVPWTd) and fractional shortening (FS) of rats after isoproterenol (ISO) injection. The upper panels show typical echocardiograms at the indicated times. (C, D) Western blot analysis of Tom70 protein in the hearts of rats subjected to ISO injection (C) and mice after TAC (D). GAPDH from the lysates was immunoblotted as a loading control. n = 8 per animals with pathological cardiac hypertrophy; n = 6 per control. The data represent the means ± SEM. *P < 0.05 versus the respective control, as determined using one-way ANOVA.