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. 2014 Aug 4;6:17. doi: 10.1186/2045-824X-6-17

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Copyright © 2014 Biel et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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VEGF inhibition in Caki-2 cell induced angiogenesis. Mice bearing window chambers with Caki-2 tumors were treated with VEGF inhibitor (Sunitinib). (A) Tumor volume and (B) tumor microvascular response to Sunitinib was evaluated compared to control. Median + 90/10 percentile; control (n = 8), Sunitinib (n = 7) (combination of two independent experiments). **, p < 0.01, Mann–Whitney U-Test.