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. Author manuscript; available in PMC: 2014 Aug 6.
Published in final edited form as: Sci Transl Med. 2010 Oct 27;2(55):55ra79. doi: 10.1126/scitranslmed.3001447

Fig. 4.

Fig. 4

Thermal enhancement with gold nanoshells in combination with radiation prevented the increase in ALDH+ seen with radiation. (A and C) Tumor volume decreased significantly with both the IR (red triangle) and the IR+HT (yellow diamond). The percent of ALDH+in the mock treatment was averaged to calculate the percent change. (B and D) IR treatment (red columns) significantly increased the percent of ALDH+, and IR+HT (yellow columns) prevented the increase in ALDH+. These data are representative of six tumors from different mice per treatment. (E) The MSFE of mock treatment was averaged to calculate the percent change. Secondary MSFE was significantly higher in IR-treated cells (red columns) and significantly decreased in the IR+HT treatment group (yellow columns). (F) EdU incorporation was significantly increased in IR-treated cells (red columns) and significantly decreased in IR+HT (yellow columns). Sample FACS profiles in fig. S5. These data are representative of three tumors from different mice with six technical replicates performed for each tumor (*P < 0.05; **P < 0.001).