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. Author manuscript; available in PMC: 2014 Aug 6.
Published in final edited form as: Sci Transl Med. 2010 Oct 27;2(55):55ra79. doi: 10.1126/scitranslmed.3001447

Fig. 6.

Fig. 6

HSPs and pAKT were activated in CSC subpopulations after treatment with IR, but not with IR+HT. The percent of ALDH+in the mock treatment was averaged to calculate the percent change in (A) and (B). (A) HSP40, HSP60, HSP70, and HSP90α have increased expression after IR (red columns) and decreased expression after IR+HT (yellow columns) 72 hours after treatment. HSP27 was increased in both treatments compared to mock. (B) The relative expression of pAKT is slightly increased after IR (red columns) and significantly decreased below mock treatment in IR+HT (yellow columns). (C) HSP90α is slightly increased after IR (red columns), but significantly decreased in IR+HT (yellow columns), compared with mock treatment (blue columns) in tumor T1. The percent of the Lin−CD29HCD24H population in the mock treatment group was averaged to calculate the percent change. (D) The relative expression of pAKT is significantly increased after IR (red columns) and is similar to mock treatment in IR+HT (yellow columns). (*P < 0.01; **P < 0.001)