Table 4.
Infectious complications after CFAR for relapsed or refractory CLL
| Early infections, n |
Late infections,* n |
|||
|---|---|---|---|---|
| Grade 3 or 4 | Grade 1 or 2 | Grade 3 or 4 | Grade 1 or 2 | |
| Pneumonia | 25 | 4 | 8 | 2 |
| Bacterial | 6 | 0 | 1 | 0 |
| Fungal† | 5 | 0 | 4 | 0 |
| Viral | 5 | 0 | 0 | 0 |
| No organism | 9 | 0 | 3 | 2 |
| Bacteremia | 4 | 0 | 0 | 0 |
| URTI/sinusitis | 4 | 18 | 1 | 1 |
| UTI | 3 | 5 | 0 | 0 |
| Skin/cellulitis | 1 | 3 | 2 | 3 |
| Other bacterial | 2 | 2 | 0 | 1 |
| Fever/neutropenic fever | 5 | 2 | 1 | 1 |
| Viral | ||||
| CMV | 5 | 1 | 3 | 1 |
| HSV/HZV | 3 | 4 | 1 | 1 |
| Other | 1 | 0 | 0 | |
| Other nonbacterial | 0 | 7 | 0 | 1 |
| Any infection, no. (%) of patients | 37 (46) | 34 (43) | 10 (28*) | 7 (19*) |
URTI indicates upper respiratory tract infection; UTI, urinary tract infection; HSV, herpes simplex virus; and HZV, herpes zoster virus.
*
A total of 36 patients evaluable for late infections.
†
Early fungal pneumonias include Aspergilloma (1), probable mould (3), histoplasmosis (1), late fungal infections include Aspergilloma (1), or probable mould (3).