Table 2.

Common Regulator and Common Target proteins with highest connectivity with the 28 differentially expressed proteins

Common Regulator*	Common Target*
Tumor necrosis factor	Mitogen-activated protein kinase 1
Transforming growth factor, beta 1	Tumor necrosis factor
Mitogen-activated protein kinase 14	F-actin
Coagulation factor II (thrombin)	Tumor protein p53
Interferon, gamma	Amyloid beta (A4) precursor protein
Cyclin-dependent kinase 1	B-cell CLL/lymphoma 2
Sp1 transcription factor	Heat shock 70kDa protein 1A
v-Src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	v-Akt murine thymoma viral oncogene homolog 1
Mitogen-activated protein kinase 1	Androgen receptor
Insulin	Apolipoprotein B (including Ag(x) antigen)
Hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
v-Akt murine thymoma viral oncogene homolog 1
Interleukin 1, beta
Caspase 3, apoptosis-related cysteine peptidase
Poly (ADP-ribose) polymerase 1
Casein kinase II

^*These proteins had connectivity with 4 or more input proteins in the pathway analysis.