Table 2.
Common Regulator and Common Target proteins with highest connectivity with the 28 differentially expressed proteins
Common Regulator* | Common Target* |
---|---|
Tumor necrosis factor | Mitogen-activated protein kinase 1 |
Transforming growth factor, beta 1 | Tumor necrosis factor |
Mitogen-activated protein kinase 14 | F-actin |
Coagulation factor II (thrombin) | Tumor protein p53 |
Interferon, gamma | Amyloid beta (A4) precursor protein |
Cyclin-dependent kinase 1 | B-cell CLL/lymphoma 2 |
Sp1 transcription factor | Heat shock 70kDa protein 1A |
v-Src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | v-Akt murine thymoma viral oncogene homolog 1 |
Mitogen-activated protein kinase 1 | Androgen receptor |
Insulin | Apolipoprotein B (including Ag(x) antigen) |
Hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | |
v-Akt murine thymoma viral oncogene homolog 1 | |
Interleukin 1, beta | |
Caspase 3, apoptosis-related cysteine peptidase | |
Poly (ADP-ribose) polymerase 1 | |
Casein kinase II |
These proteins had connectivity with 4 or more input proteins in the pathway analysis.