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. Author manuscript; available in PMC: 2014 Oct 4.
Published in final edited form as: J Proteome Res. 2013 Sep 12;12(10):4366–4375. doi: 10.1021/pr4003432

Table 2.

Common Regulator and Common Target proteins with highest connectivity with the 28 differentially expressed proteins

Common Regulator* Common Target*
Tumor necrosis factor Mitogen-activated protein kinase 1
Transforming growth factor, beta 1 Tumor necrosis factor
Mitogen-activated protein kinase 14 F-actin
Coagulation factor II (thrombin) Tumor protein p53
Interferon, gamma Amyloid beta (A4) precursor protein
Cyclin-dependent kinase 1 B-cell CLL/lymphoma 2
Sp1 transcription factor Heat shock 70kDa protein 1A
v-Src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) v-Akt murine thymoma viral oncogene homolog 1
Mitogen-activated protein kinase 1 Androgen receptor
Insulin Apolipoprotein B (including Ag(x) antigen)
Hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
v-Akt murine thymoma viral oncogene homolog 1
Interleukin 1, beta
Caspase 3, apoptosis-related cysteine peptidase
Poly (ADP-ribose) polymerase 1
Casein kinase II
*

These proteins had connectivity with 4 or more input proteins in the pathway analysis.