Table 2.

Hazard ratios for all-cause mortality in the study population

Variable	Univariate		Final Modela
	HR (95% CI)	P Value	HR (95% CI)	P Value
Skin autofluorescence (versus lowest quartile)
Quartile 2	0.98 (0.58 to 1.63)	<0.001b	0.82 (0.49 to 1.38)	0.39b
Quartile 3	1.61 (1.01 to 2.57)		0.95 (0.59 to 1.53)
Highest quartile	2.64 (1.71 to 4.08)		1.21 (0.76 to 1.93)
Sex (men versus women)	1.95 (1.45 to 2.63)	<0.001	1.27 (0.91 to 1.78)	0.16
Age, yr	1.09 (1.07 to 1.12)	<0.001	1.06 (1.04 to 1.09)	<0.001
Cardiovascular disease (versus no cardiovascular disease)	3.15 (2.33 to 4.26)	<0.001	2.17 (1.58 to 2.98)	<0.001
Diabetes (versus no diabetes)	1.54 (1.09 to 2.19)	0.02	1.10 (0.75 to 1.62)	0.62
Hypertension (versus no hypertension)	1.24 (0.76 to 2.03)	0.38
Smoking (versus never smokers)
Current smoker	1.50 (0.74 to 3.02)	0.01b	2.06 (0.99 to 4.31)	0.15
Ex-smoker	1.67 (1.22 to 2.29)		1.17 (0.83 to 1.65)
Body mass index, kg/m2	0.97 (0.94 to 1.00)	0.05	0.99 (0.96 to 1.03)	0.77
Central obesity (versus not centrally obese)	0.89(0.60 to 1.32)	0.56
Total-to-HDL cholesterol ratio	0.99 (0.87 to 1.12)	0.87
eGFR, ml/min per 1.73 m2 (continuous)	0.94 (0.93 to 0.95)	<0.001	0.97 (0.95 to 0.99)	<0.001
Log average uACR, mg/mmol	1.35 (1.22 to 1.51)	<0.001	1.15 (1.03 to 1.28)	0.02
Hemoglobin, g/dl	0.80 (0.72 to 0.89)	<0.001	0.94 (0.84 to 1.05)	0.30
Qualifications (versus none)
School level	1.56 (1.00 to 2.46)	0.12b
Degree or equivalent	1.27 (0.76 to 2.11)
IMD quintiles (versus least deprived)
1 (most deprived)	1.06 (0.55 to 2.05)	0.75b
2	1.26 (0.80 to 1.98)
3	1.22 (0.75 to 1.99)
4	1.33 (0.86 to 2.07)

All variables are continuous except sex, cardiovascular disease, diabetes, hypertension, smoking status, and central obesity. HR, hazard ratio; 95% CI, 95% confidence interval.

^aAdjusted for age, sex, cardiovascular disease, diabetes, smoking, body mass index, eGFR, albuminuria, and hemoglobin.

^bP value for trend.