Table 2.
Summary of change from baseline in SBP and DBP as a function of dose
| BP (mg/kg per d) | n | Baseline (mmHg) | Week 3 (mmHg) | Change from Baseline | Least-Squares Change from Baseline (mmHg)a |
|---|---|---|---|---|---|
| SBP | |||||
| Low (0.1) | 32 | 111.2 (8.8) | 103.9 (12.8) | −7.3 (12.5) | −7.41 (−10.8 to −4.1) |
| Medium (0.3) | 34 | 113.7 (8.2) | 106.1 (9.4) | −7.7 (7.5) | −7.6 (−10.9 to −4.3) |
| High (0.7) | 33 | 111.2 (7.2) | 104.5 (9.8) | −6.7 (7.9) | −6.8 (−10.1 to −3.4) |
| DBP | |||||
| Low (0.1) | 32 | 68.8 (6.1) | 60.6 (10.4) | −8.3 (11.8) | −8.3 (−11.7 to −5.0) |
| Medium (0.3) | 34 | 69.3 (8.6) | 64.2 (9.2) | −5.2 (8.1) | −5.3 (−8.6 to −2.0) |
| High (0.7) | 33 | 68.6 (7.4) | 61.9 (6.4) | −6.7 (8.6) | −6.7 (−10.0 to −3.4) |
Data are presented as the mean (SD) or mean change (95% confidence interval).
a
From analysis of covariance model with terms for dose as a factor, weight as a continuous covariate, and presence of comorbidities/end organ damage.