Table 2.

The association between KIM-1/creatinine and cardiovascular and total mortality: incidence rates and multivariable cox regression

Mortality	Events/ At Risk (n)	Incidence Rate per 100 Person-Years at Risk (95% CI)	Hazard Ratio (95% CI)
			Model A	Model B	Model C
Cardiovascular mortality
Continuous models
1-SD increase (91 ng/mmol)			1.50 (1.29 to 1.75)a	1.45 (1.22 to 1.71)a	1.27 (1.05 to 1.54)b
Threshold models
Q1–Q4 (<175 ng/mmol)	59/472	16.6 (12.9 to 21.4)	Referent	Referent	Referent
Q5 (≥175 ng/mmol)	30/118	38.1 (26.7 to 54.5)	2.34 (1.51 to 3.64)a	2.08 (1.33 to 3.27)b	1.72 (1.07 to 2.76)c
Total mortality
Continuous models
1-SD increase			1.30 (1.16 to 1.47)a	1.24 (1.10 to 1.41)a	1.12 (0.98 to 1.29)
Threshold models
Q1–Q4 (<175 ng/mmol)	148/472	41.6 (35.4 to 48.9)	Referent	Referent	Referent
Q5 (≥175 ng/mmol)	50/118	63.6 (48.2 to 83.9)	1.56 (1.13 to 2.14)b	1.42 (1.02 to 1.97)c	1.20 (0.85 to 1.69)

Data are presented as the incident rate (95% CI) or hazard ratio (95% CI) unless otherwise specified. Model A is adjusted for age. Model B is adjusted for age and established cardiovascular risk factors such as known cardiovascular disease at baseline, antihypertensive treatment, lipid-lowering treatment, low-dose aspirin treatment, current smoking, diabetes, systolic BP, body mass index, total cholesterol, and HDL cholesterol. Model C is adjusted for age, established cardiovascular risk factors, eGFR, and albumin/creatinine ratio. 95% CI, 95% confidence interval.

^aP<0.001.

^bP<0.01.

^cP<0.05.