. 2014 Jun 12;9(8):1393–1401. doi: 10.2215/CJN.11901113

Table 4.

Data portraying the interplay between KIM-1/creatinine, eGFR, and albuminuria and the risk for total and cardiovascular mortality: Cox regression

Groups According to eGFR, Albuminuria, and  KIM-1/Creatinine Status^a	Total Mortality			Cardiovascular Mortality
	Events/ At Risk (n)	Hazard Ratio (95% CI)		Events/ At Risk (n)	Hazard Ratio (95% CI)
	Events/ At Risk (n)	Model A	Model B	Events/ At Risk (n)	Model A	Model B
Normal eGFR, normal ACR and normal KIM-1/creatinine	82/342	Referent	Referent	30/342	Referent	Referent
Normal eGFR, normal ACR, and high KIM-1/creatinine	19/52	1.70  (1.03 to 3.80)^b	1.60  (0.97 to 2.65)	10/52	2.45  (1.20 to 5.01)^b	2.29  (1.11 to 4.70)^b
Low eGFR, high ACR or both, and normal KIM-1/creatinine	66/131	2.42  (1.75 to 3.25)^c	2.18  (1.55 to 3.06)^c	29/131	2.93  (1.76 to 4.90)^c	2.35  (1.38 to 4.01)^d
Low eGFR or high ACR, and high KIM-1/creatinine	19/45	2.14  (1.30 to 3.52)^d	1.84  (1.09 to 3.12)^b	10/45	3.09  (1.51 to 6.33)^d	2.44  (1.14 to 5.19)^b
Low eGFR, high ACR and high KIM-1/creatinine	12/20	3.69  (2.01 to 6.77)^c	3.31  (1.76 to 6.23)^c	10/20	8.56  (4.18 to 17.56)^c	6.87  (3.21 to 14.73)^c

Model A is adjusted for age. Model B is adjusted for age and established cardiovascular risk factors such as known cardiovascular disease at baseline, antihypertensive treatment, lipid-lowering treatment, low-dose aspirin treatment, current smoking, diabetes, systolic BP, body mass index, total cholesterol, and HDL cholesterol. ACR, albumin/creatinine ratio.

Normal eGFR, ≥60 ml/min per 1.73 m²; low eGFR, ≤60 ml/min per 1.73 m²; normal ACR, <3 g/mol; microalbuminuria/macroalbuminuria, ACR≥3 g/mol; normal KIM-1/creatinine, <175 ng/mmol; and high KIM-1/creatinine, ≥175 ng/mmol.

P<0.05.

P<0.001.

P<0.01.