Table 1.

Main characteristics of the more frequent de novo GN after transplantation

Disease	Presentation	Time of Onset	Difference with Native GN	Treatment	Prognosis
MCD	NS	Early after transplant	Mild mesangial sclerosis, hypercellularity	Steroids	Good
FSGS	Proteinuria, rarely in nephrotic range	Months or years after transplant	NS is rare; signs of rejection or calcineurin inhibitor toxicity at biopsy	Removal of associated events	Usually poor, particularly in collapsing GN
MN	Proteinuria sometimes in nephrotic range	Late after transplant	Associated with transplant complications; IgG1 deposits instead of IgG4	No specific treatment	Slowly progressive
MPGN	Proteinuria, hematuria, NS, nephritic sediment	Months or years after transplant	Often associated with HCV infection, sometimes with other diseases	Steroids+cytotoxic drugs if crescentic GN (?)	Slowly progressive; poor with many crescents
IgAN	Hematuria, proteinuria		Macroscopic hematuria is infrequent	Steroids+cytotoxic drugs if crescentic GN (?)	Usually good but poor in patients with crescentic GN

MCD, minimal change disease; NS, nephrotic syndrome; MN, membranous nephropathy; MPGN, membranoproliferative GN; HCV, hepatitis C virus; IgAN, IgA nephritis.