Table 3.

NCI responses at respective assessment time points and best response achieved for all patients

No. on Rx/ITT	Evaluation cycle
	3 cycles, no. (%) 54/60*	9 cycles, no. (%) 43/60	15 cycles, no. (%) 38/60	21 cycles, no. (%) 35/60	Best response, no. (%) 60
Response †
CR	0	1 (2)	3 (5)	5 (8)	6 (10)
CRi	0	0	2 (3)	3 (5)	3 (5)
nPR	0	6 (10)	4 (7)	5 (8)	4 (7)
PR	24 (40)	27 (45)	27 (45)	22 (37)	26 (43)
ORR	24 (40)	34 (57)	36 (60)	35 (58)	39 (65)
DC(PR)	0	1	0	1

Rx indicates therapy; ITT, intention-to-treat; nPR, nodular partial response; and DC(PR), discontinued in PR.

^*One patient not evaluable.

^†2008 NCI working group criteria for response.