Table 3.
SNPs nominally associated with CSF MHPG concentrations in psychotic patients
| |
Patients with psychosis (n = 74; 45 men, 29 women) |
Healthy controls (n = 111; 63 men, 48 women) |
|||||
|---|---|---|---|---|---|---|---|
|
MHPG mean (S.D.) |
43.3 (9.3) nmol/l |
41.7 (8.1) nmol/l |
|||||
| Gene | SNP | MAF(%) | HWE | P | MAF (%) | HWE | P |
|
MAOB (men) |
rs5905512 |
47 |
|
0.0004 |
50 |
|
0.479 |
|
MAOB (men) |
rs1799836 |
38 |
|
0.0008 |
44 |
|
0.483 |
|
DDC |
rs11575535 |
4 |
1.000 |
0.005 |
4 |
1.000 |
0.126 |
|
TPH1 |
rs4537731 |
44 |
0.475 |
0.007 |
40 |
0.047 |
0.646 |
|
DDC |
rs6592961 |
28 |
0.400 |
0.008 |
29 |
0.104 |
0.855 |
|
TPH1 |
rs7933505 |
41 |
0.148 |
0.010 |
41 |
0.334 |
0.342 |
|
DDC |
rs7809758 |
40 |
0.811 |
0.013 |
38 |
0.159 |
0.956 |
|
TPH1 |
rs7122118 |
43 |
0.239 |
0.014 |
40 |
0.029 |
0.821 |
|
DBH |
rs6271 |
3 |
1.000 |
0.017 |
5 |
1.000 |
0.340 |
|
TPH1 |
rs1799913 |
42 |
0.096 |
0.017 |
41 |
0.334 |
0.342 |
|
TPH1 |
rs684302 |
42 |
0.232 |
0.017 |
41 |
0.171 |
0.397 |
|
DDC |
rs9942686 |
21 |
0.723 |
0.018 |
23 |
1.000 |
0.189 |
|
MAOB (men) |
rs6651806 |
24 |
|
0.021 |
32 |
|
0.328 |
|
DDC |
rs17133853 |
11 |
1.000 |
0.033 |
9 |
0.569 |
0.436 |
|
DBH |
rs1611115 |
21 |
1.000 |
0.035 |
14 |
1.000 |
0.791 |
|
DBH |
rs3025388 |
18 |
0.445 |
0.047 |
18 |
0.517 |
0.064 |
|
TPH1 |
rs12292915 |
44 |
0.161 |
0.047 |
43 |
0.052 |
0.066 |
| TPH1 | rs211105 | 31 | 0.785 | 0.049 | 25 | 0.449 | 0.033 |
Minor allele frequencies (MAF), p-values of testing for Hardy–Weinberg equilibrium (HWE) and p-values (P) from multiple linear regressions of single nucleotide polymorphisms (SNPs) nominally associated with 3-methoxy-4-hydroxyphenylglycol (MHPG) concentrations in the cerebrospinal fluid of psychotic patients and the corresponding association statistics among healthy controls. MAOA and MAOB are located on chromosome X and the analyses were therefore conducted separately for men and women.