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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Br J Haematol. 2014 Feb 26;165(5):640–648. doi: 10.1111/bjh.12801

Figure 1. Histological Findings in PCNSL.

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Figure 1

Histological sections of a representative central nervous system biopsy shows an atypical lymphoid proliferation infiltrating brain parenchyma in a diffuse pattern (A); the lymphoma cells typically surround vessels and cause angiocentric and angiodestructive lesions (B); higher magnification shows marked cytological atypia of the lymphoma cells with pleomorphic nuclear outlines, prominent nucleoli and associated mitotic figures (C); immunohistochemistry shows that the lymphoma cells are positive for HGAL (D), LMO2 (E) and BCL6 (F). [Original magnification, panel A x200, panel B x400, panels C-F x600].