Table 1.

Weight and Cardiorespiratory Variables

	High-Strain (n=6)		High-Strain LPS (n=6)		Low-Strain LPS (n=6)
	Baseline	End	Baseline	End	Baseline	End
Weight, kg	20 (18–21)		23 (21–24)		20 (19–21)
VT, mL·kg−1	18.2 (17.0–23.5)b	20.0 (13.9–24.3)b	18.8 (15.9–21.5)b	13.8 (11.5–18.7)b,e	8.1 (8.0–8.3)	8.0 (7.9–8.1)
PEEP, cmH2O	0 ± 0b	0 ± 0 b	0 ± 0 b	0 ± 0b	17 ± 3	17 ± 2
RR, bpm	19 ± 1b	19 ± 3	19 ± 2b	21 ± 3	25 ± 2	26 ± 2
FIO2	0.3 (0.3–0.3)	0.35 (0.3–0.4)	0.3 (0.3–0.35)	0.35 (0.3–0.6)	0.3 (0.3–0.4)	0.3 (0.3–0.4)
CO, L·min−1	5.9 ± 1.3 b	6.3 ± 1.2b	4.4 ± 1.1	4.4 ± 0.7 b,c	3.3 ± 0.7	3.2 ± 0.5
MAP, mmHg	74 ± 14	81c 13	92 ± 12	78 ± 13 f	87 ± 13	81 ± 13
MPAP, mmHg	14 ± 8	15 ± 9 b	16 ± 9	21 ± 5 a	22 ± 6	32 ± 6 f
PaO2/FiO2, torr	243 ± 66	228 ± 88	255 ± 74	162 ± 67d	351 ± 117	261 ± 112
PaCO2, torr	34 (30±41)	36 (32±51)	33 (30±40)	43 (41±46)	39 (36±42)	39 (33±43)

V_T=tidal volume; PEEP=positive end-expiratory pressure; RR=respiratory rate; F_IO₂=inspired O₂ fraction; CO=cardiac output; MAP=mean arterial pressure; MPAP=mean pulmonary arterial pressure; P_aO₂=arterial O₂ pressure; P_aCO₂=arterial CO₂ pressure. Data are shown as mean ± standard deviation if normally distributed, or median (25^th–75^th percentile) otherwise. Groups were compared using ANOVA with Tukey-Kramer post-hoc tests for normally distributed data, or Kruskall-Wallis with Bonferroni-corrected post-hoc tests otherwise, Time points were compared using paired t-tests.

^ap<0.05 vs. Low-Strain LPS group.

^bp<0.01 vs. Low-Strain LPS group.

^cp<0.05 vs. High-Strain group.

^dp<0.10 vs baseline.

^ep<0.05 vs baseline.

^fp<0.01 vs baseline.