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. 2014 Jan 30;35(8):1707–1716. doi: 10.1093/carcin/bgu023

Fig. 3.

Fig. 3.

Fibulin-3 downregulation and promoter methylation were correlated with MMP-7 expression in lung tumors. (A) Comparison of immunostaining of fibulin-3 and MMP-7 in NSCLC. Representative pictures of two fibulin-3-/MMP-7+ tumors are shown (×400). Arrows indicate examples of MMP-7-positive cells. Scale bar, 25 μm. (B) Summary of fibulin-3 and MMP-7 expression in 101 NSCLC samples (Supplementary Table 1, available at Carcinogenesis Online). The inverse correlation between fibulin-3 and MMP-7 expression was statistically significant (P < 0.05, two-tailed χ2 test). (C) Top: Summary of fibulin-3 and MMP-7 expression and MMP-7 promoter methylation in an independent set of 32 pairs of lung tumors and matched pathologically normal lung tissues. Bottom: Correlation of MMP-7 expression and fibulin-3 promoter methylation in lung tumors (P < 0.05, two-tailed χ2 test).