Table III.
Associations between IL genes and risk of breast cancer by genetic ancestry, menopausal status and ER/PR tumor status
| Overall | SNP | Genotype | Controls, N | Cases, N | ORa | 95% CI |
|---|---|---|---|---|---|---|
| Risk versus referent | Risk versus referent | |||||
| IL1A | rs3783546 | CC versus GG/GC | 887/3268 | 635/2931 | 0.85 | (0.76, 0.96) |
| IL1B | rs1143633 | AA versus GG | 425/1938 | 428/1567 | 1.21 | (1.04, 1.41) |
| rs1143627 | TC/CC versus TT | 2960/1188 | 2404/1155 | 0.90 | (0.81, 0.99) | |
| IL1RN | rs4251961 | TC/CC versus TT | 2243/1912 | 1830/1739 | 0.86 | (0.79, 0.94) |
| rs2232354 | TG/GG versus TT | 1509/2643 | 1205/2358 | 0.89 | (0.81, 0.98) | |
| rs452204 | AA versus GG/GA | 843/3312 | 777/2783 | 1.13 | (1.01, 1.26) | |
| rs397211 | CC versus TT | 722/1519 | 638/1281 | 1.16 | (1.01, 1.33) | |
| IL2 | rs2069776 | TC/CC versus TT | 1375/2781 | 1314/2253 | 1.12 | (1.02, 1.24) |
| rs2069778 | CT/TT versus CC | 689/3468 | 694/2875 | 1.13 | (1.00, 1.28) | |
| IL2RA | rs9663421 | TT versus CC | 496/1848 | 366/1674 | 0.85 | (0.73, 0.99) |
| rs2386841 | AA versus CC/CA | 447/3709 | 275/3293 | 0.75 | (0.64, 0.89) | |
| rs11256457 | GC/CC versus GG | 2959/1197 | 2661/908 | 1.11 | (1.00, 1.23) | |
| rs10905669 | TT versus CC/CT | 456/3701 | 294/3275 | 0.77 | (0.66, 0.90) | |
| IL4 | rs2227282 | GG versus CC/CG | 1061/3093 | 764/2804 | 0.87 | (0.77, 0.98) |
| IL6 | rs1800797 | GT/TT versus GG | 1794/2363 | 1525/2042 | 0.88 | (0.79, 0.97) |
| rs1800795 | GC/CC versus GG | 1827/2330 | 1556/2011 | 0.88 | (0.80, 0.97) | |
| rs2069832 | GA/AA versus GG | 1828/2329 | 1553/2013 | 0.88 | (0.79, 0.97) | |
| rs2069840 | GG versus CC | 417/1894 | 416/1573 | 1.18 | (1.01, 1.37) | |
| IL10 | rs1554286 | TT versus CC/CT | 454/3703 | 284/3283 | 0.76 | (0.65, 0.89) |
| rs1518111 | AA versus GG/GA | 533/3624 | 342/3226 | 0.77 | (0.66, 0.89) | |
| rs1800871 | TT versus CC/CT | 557/3598 | 368/3201 | 0.79 | (0.68, 0.91) | |
| Genetic ancestry: <29% | ||||||
| IL1B | rs1143633 | AA versus GG | 220/800 | 256/688 | 1.36 | (1.10, 1.67) |
| IL6 | rs1800797 | GA/AA versus GG | 1164/683 | 1030/711 | 0.85 | (0.74, 0.98) |
| rs1800795 | GC/CC versus GG | 1187/660 | 1047/694 | 0.84 | (0.73, 0.97) | |
| rs2069832 | GA/AA versus GG | 1186/661 | 1053/687 | 0.86 | (0.75, 0.99) | |
| IL6R | rs1386821 | AC/CC versus AA | 621/1226 | 637/1102 | 1.15 | (1.00, 1.32) |
| rs7549250 | TC/CC versus TT | 1281/566 | 1123/619 | 0.81 | (0.70, 0.93) | |
| IL10 | rs1554286 | TT versus CC/CT | 78/1769 | 49/1693 | 0.66 | (0.46, 0.95) |
| rs1518111 | AA versus GG/GA | 116/1731 | 76/1665 | 0.68 | (0.50, 0.91) | |
| rs1800871 | TT versus CC/CT | 129/1718 | 92/1650 | 0.74 | (0.56, 0.98) | |
| Genetic ancestry: >70% | ||||||
| IL2 | rs2069778 | CT/TT versus CC | 21/608 | 33/404 | 2.21 | (1.24, 3.92) |
| IL2RA | rs12722605 | AT/TT versus AA | 60/569 | 23/414 | 0.51 | (0.31, 0.85) |
| rs9663421 | TT versus CC | 113/206 | 57/181 | 0.57 | (0.39, 0.84) | |
| rs11256457 | GC/CC versus GG | 312/317 | 254/183 | 1.34 | (1.04, 1.73) | |
| rs791587 | GA/AA versus GG | 372/257 | 284/153 | 1.30 | (1.00, 1.68) | |
| rs10905669 | TT versus CC/CT | 140/489 | 63/374 | 0.56 | (0.40, 0.78) | |
| Menopausal status | ||||||
| Premenopausal | ||||||
| IL1A | rs3783546 | CC versus GG/GC | 343/1172 | 239/1077 | 0.81 | (0.67, 0.99) |
| IL1B | rs1143633 | AA versus GG | 149/740 | 150/574 | 1.29 | (1.00, 1.67) |
| IL2 | rs2069778 | CT/TT versus CC | 225/1291 | 263/1055 | 1.31 | (1.07, 1.61) |
| IL3 | rs40401 | CT/TT versus CC | 693/821 | 543/775 | 0.82 | (0.71, 0.95) |
| Postmenopausal | ||||||
| IL2RA | rs9663421 | TT versus CC | 296/1131 | 197/1031 | 0.76 | (0.62, 0.93) |
| rs12722596 | AG/GG versus AA | 327/2229 | 340/1824 | 1.24 | (1.05, 1.46) | |
| rs7072398 | GG versus AA | 439/920 | 450/682 | 1.27 | (1.07, 1.51) | |
| rs11256457 | GC/CC versus GG | 1841/714 | 1651/513 | 1.18 | (1.03, 1.35) | |
| rs6602398 | TT versus GG/GT | 242/2314 | 162/2002 | 0.76 | (0.61, 0.93) | |
| rs10905669 | TT versus CC/CT | 281/2275 | 181/1983 | 0.77 | (0.63, 0.95) | |
| IL6 | rs2069827 | GT/TT versus GG | 296/2260 | 226/1937 | 0.82 | (0.68, 0.99) |
| rs1800797 | GA/AA versus GG | 1141/1415 | 952/1211 | 0.87 | (0.77, 0.99) | |
| rs1800795 | GC/CC versus GG | 1166/1390 | 976/1186 | 0.88 | (0.78, 1.00) | |
| rs2069832 | GA/AA versus GG | 1167/1389 | 977/1186 | 0.88 | (0.78, 1.00) | |
| IL10 | rs1554286 | TT versus CC/CT | 255/2301 | 166/1997 | 0.81 | (0.66, 1.00) |
| rs1518111 | AA versus GG/GA | 310/2246 | 196/1967 | 0.77 | (0.63, 0.93) | |
| Tumor phenotype | ||||||
| ER+/PR+ | ||||||
| IL1RN | rs4251961 | TC/CC versus TT | 1819/1352 | 698/600 | 0.84 | (0.74, 0.96) |
| rs2232354 | TG/GG versus TT | 1186/1982 | 430/866 | 0.83 | (0.72, 0.95) | |
| rs452204 | AA versus GA/AA | 554/2617 | 263/1034 | 1.22 | (1.03, 1.44) | |
| rs315949 | CT/TT versus CC | 1892/1281 | 737/561 | 0.85 | (0.74, 0.97) | |
| IL10 | rs1554286 | TT versus CC/CT | 264/2909 | 70/1227 | 0.68 | (0.51, 0.89) |
| rs1518111 | AA versus GG/GA | 323/2850 | 92/1206 | 0.72 | (0.56, 0.91) | |
| rs1800871 | TT versus CC/CT | 348/2823 | 104/1194 | 0.74 | (0.59, 0.94) | |
| ER+/PR− | ||||||
| IL15 | rs12498901 | GC/CC versus GG | 682/2491 | 38/197 | 0.70 | (0.49, 1.00) |
| rs6850492 | AA versus GG | 398/1326 | 23/124 | 0.58 | (0.36, 0.92) | |
| IL23R | rs10889677 | AA versus CC | 315/1528 | 13/130 | 0.49 | (0.27, 0.88) |
| rs12030948 | TT versus GG | 427/1286 | 18/111 | 0.49 | (0.29, 0.82) | |
| rs10489629 | AA versus GG | 839/767 | 44/64 | 0.63 | (0.42, 0.93) | |
| rs10489628 | CT/TT versus CC | 2140/1033 | 179/56 | 1.54 | (1.13, 2.11) | |
| rs6693831 | CT/TT versus CC | 1722/1451 | 142/93 | 1.35 | (1.02, 1.78) | |
| rs11465817 | CA/AA versus CC | 1468/1531 | 92/131 | 0.73 | (0.55, 0.97) | |
| rs10889675 | AA versus CC | 177/1987 | 20/129 | 2.02 | (1.20, 3.40) | |
| ER−/PR− | ||||||
| IL4 | rs2243250 | TT versus CC | 279/1735 | 54/215 | 1.56 | (1.09, 2.22) |
| rs2243263 | GC/CC versus GG | 765/2408 | 72/343 | 0.66 | (0.50, 0.86) | |
aOR and 95% CI adjusted for age, study center, parity, BMI during the referent year and genetic admixture.