Table V.
Associations between lifestyle factors in IL genes
| Low | Intermediate | High | P interaction | |||||
|---|---|---|---|---|---|---|---|---|
| ORa | 95% CI | OR | 95% CI | OR | 95% CI | Raw | Lasso | |
| Energy intake | ||||||||
| IL2RA (rs2104286) | ||||||||
| AA | 1 | 1.36 | (1.18, 1.57) | 1.77 | (1.51, 2.07) | 0.005 | <0.0001 | |
| AG/GG | 1.34 | (1.09, 1.64) | 1.37 | (1.15, 1.62) | 1.58 | (1.28, 1.94) | ||
| IL10 (rs3024493) | ||||||||
| GG | 1 | 1.29 | (1.13, 1.47) | 1.69 | (1.46, 1.96) | 0.01 | <0.0001 | |
| GT/TT | 1.37 | (1.08, 1.74) | 1.43 | (1.19, 1.71) | 1.49 | (1.16, 1.90) | ||
| Dietary folate | ||||||||
| IL17A (rs3819024) | ||||||||
| AA | 1 | 0.84 | (0.73, 0.98) | 0.68 | (0.57, 0.82) | 0.04 | <0.0001 | |
| AG | 0.87 | (0.73, 1.05) | 0.83 | (0.70, 0.97) | 0.70 | (0.58, 0.86) | ||
| GG | 0.80 | (0.59, 1.09) | 0.84 | (0.65, 1.10) | 0.89 | (0.62, 1.29) | ||
| BMI | ||||||||
| <25kg/m2 | 25–30kg/m2 | >30kg/m2 | ||||||
| IL6 (rs2069832) | ||||||||
| GG | 1 | 0.86 | (0.73, 1.01) | 0.7 | (0.60, 0.82) | 0.002 | <0.0001 | |
| GA/AA | 0.76 | (0.65, 0.90) | 0.69 | (0.58, 0.81) | 0.76 | (0.64, 0.90) | ||
aOR and 95% CI adjusted for age, study, BMI during referent year, parity and genetic admixture.