Table VI.
Associations between IL genes and all-cause mortality and breast cancer-specific mortality
| All women | 0–28% NA ancestry | 29–100% NA ancestry | Interaction | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Deaths/person year | HRa | (95% CI) | Deaths/person year | HRa | (95% CI) | Deaths/person year | HRa | (95% CI) | P valueb | |
| All-cause mortality | ||||||||||
| IL2RA (rs12244380) | ||||||||||
| AA | 167/7078 | 1.00 | 86/3933 | 1.00 | 81/3146 | 1.00 | 0.10 | |||
| AG | 221/11058 | 0.84 | (0.69, 1.03) | 146/6551 | 0.98 | (0.75, 1.28) | 75/4507 | 0.66 | (0.48, 0.90) | |
| GG | 64/4325 | 0.61 | (0.46, 0.81) | 44/2772 | 0.70 | (0.49, 1.01) | 20/1553 | 0.46 | (0.28, 0.75) | |
| IL2RA (rs6602392) | ||||||||||
| CC | 335/17005 | 1.00 | 222/10427 | 1.00 | 113/6578 | 1.00 | 0.03 | |||
| CA/AA | 117/5447 | 1.07 | (0.86, 1.32) | 54/2820 | 0.88 | (0.65, 1.19) | 63/2628 | 1.39 | (1.02, 1.90) | |
| IL2RA (rs791587) | ||||||||||
| GG | 110/6368 | 1.00 | 72/3603 | 1.00 | 38/2765 | 1.00 | 0.15 | |||
| GA/AA | 342/16067 | 1.24 | (1.00, 1.54) | 204/9641 | 1.11 | (0.85, 1.45) | 138/6426 | 1.58 | (1.10, 2.27) | |
| IL2RA (rs706779) | ||||||||||
| GG | 134/6456 | 1.00 | 70/3115 | 1.00 | 64/3341 | 1.00 | 0.06 | |||
| GA | 210/10780 | 0.96 | (0.77, 1.19) | 138/6232 | 1.05 | (0.79, 1.41) | 72/4548 | 0.81 | (0.58, 1.14) | |
| AA | 107/5207 | 0.99 | (0.77, 1.29) | 68/3894 | 0.81 | (0.58, 1.13) | 39/1312 | 1.57 | (1.05, 2.35) | |
| IL2RA (rs3118470) | ||||||||||
| TT/TC | 404/20427 | 1.00 | 250/11938 | 1.00 | 154/8489 | 1.00 | 0.04 | |||
| CC | 48/2034 | 1.26 | (0.94, 1.71) | 26/1317 | 0.96 | (0.64, 1.44) | 22/717 | 1.88 | (1.20, 2.95) | |
| IL4 (rs2243250) | ||||||||||
| CC | 247/12156 | 1.00 | 186/9048 | 1.00 | 61/3109 | 1.00 | 0.88 | |||
| CT | 145/8036 | 0.91 | (0.73, 1.12) | 71/3577 | 0.92 | (0.70, 1.22) | 74/4459 | 0.87 | (0.62, 1.23) | |
| TT | 50/1769 | 1.41 | (1.01, 1.98) | 12/293 | 2.23 | (1.23, 4.03) | 38/1476 | 1.23 | (0.81, 1.87) | |
| IL4 (rs2227282) | ||||||||||
| CC/CG | 367/18981 | 1.00 | 253/12516 | 1.00 | 114/6465 | 1.00 | 0.26 | |||
| GG | 85/3472 | 1.30 | (1.01, 1.68) | 23/739 | 1.66 | (1.08, 2.56) | 62/2733 | 1.21 | (0.88, 1.66) | |
| IL4 (rs2243263) | ||||||||||
| GG | 333/17545 | 1.00 | 202/10624 | 1.00 | 131/6921 | 1.00 | 0.22 | |||
| GC/CC | 119/4902 | 1.31 | (1.06, 1.61) | 74/2617 | 1.46 | (1.12, 1.91) | 45/2285 | 1.12 | (0.79, 1.57) | |
| IL6R (rs4075015) | ||||||||||
| TT/TA | 394/18804 | 1.00 | 239/10798 | 1.00 | 155/8007 | 1.00 | 0.31 | |||
| AA | 58/3622 | 0.73 | (0.55, 0.96) | 37/2446 | 0.66 | (0.47, 0.94) | 21/1176 | 0.91 | (0.57, 1.43) | |
| IL6R (rs2229238) | ||||||||||
| CC | 248/13151 | 1.00 | 170/8146 | 1.00 | 78/5004 | 1.00 | 0.16 | |||
| CT/TT | 141/6258 | 1.24 | (1.01, 1.53) | 94/4213 | 1.10 | (0.86, 1.42) | 47/2045 | 1.51 | (1.05, 2.18) | |
| Breast cancer-specific mortality | ||||||||||
| IL4 (rs2243263) | ||||||||||
| GG | 167/17545 | 1.00 | 98/10624 | 1.00 | 69/6921 | 1.00 | 0.32 | |||
| GC/CC | 68/4902 | 1.49 | (1.12, 1.98) | 40/2617 | 1.69 | (1.17, 2.45) | 28/2285 | 1.27 | (0.82, 1.98) | |
| IL8 (rs4073) | ||||||||||
| TT | 73/7316 | 1.00 | 36/4121 | 1.00 | 37/3195 | 1.00 | 0.06 | |||
| TA | 105/10944 | 1.00 | (0.74, 1.35) | 63/6343 | 1.20 | (0.80, 1.82) | 42/4601 | 0.82 | (0.52, 1.28) | |
| AA | 56/4188 | 1.37 | (0.96, 1.94) | 39/2791 | 1.80 | (1.15, 2.84) | 17/1397 | 0.92 | (0.51, 1.65) | |
| IL8 (rs2227307) | ||||||||||
| TT | 79/7789 | 1.00 | 37/4301 | 1.00 | 42/3488 | 1.00 | 0.04 | |||
| TG | 102/10796 | 0.97 | (0.72, 1.31) | 63/6268 | 1.26 | (0.83, 1.89) | 39/4528 | 0.73 | (0.47, 1.14) | |
| GG | 54/3876 | 1.40 | (0.99, 1.98) | 38/2687 | 1.86 | (1.18, 2.93) | 16/1189 | 0.95 | (0.52, 1.73) | |
| IL8 (rs2227543) | ||||||||||
| CC | 88/9108 | 1.00 | 41/4808 | 1.00 | 47/4300 | 1.00 | 0.11 | |||
| CT | 100/10161 | 1.04 | (0.78, 1.38) | 62/6058 | 1.29 | (0.87, 1.93) | 38/4103 | 0.81 | (0.52, 1.25) | |
| TT | 47/3164 | 1.65 | (1.15, 2.37) | 35/2362 | 1.98 | (1.26, 3.12) | 12/803 | 1.32 | (0.69, 2.52) | |
| IL17A (rs8193036) | ||||||||||
| TT/TC | 212/20884 | 1.00 | 126/12127 | 1.00 | 86/8757 | 1.00 | 0.01 | |||
| CC | 22/1555 | 1.41 | (0.90, 2.19) | 11/1106 | 0.90 | (0.49, 1.67) | 11/448 | 2.90 | (1.53, 5.49) | |
| IL6R (rs4509570) | ||||||||||
| CC | 134/13678 | 1.00 | 88/7952 | 1.00 | 46/5726 | 1.00 | 0.02 | |||
| CG | 101/8784 | 1.17 | (0.90, 1.51) | 50/5303 | 0.88 | (0.62, 1.25) | 51/3480 | 1.69 | (1.13, 2.53) | |
| IL6R (rs2229238) | ||||||||||
| CC | 129/13151 | 1.00 | 88/8146 | 1.00 | 41/5004 | 1.00 | 0.10 | |||
| CT/TT | 71/6258 | 1.22 | (0.91, 1.63) | 42/4213 | 1.01 | (0.70, 1.46) | 29/2045 | 1.69 | (1.05, 2.72) | |
aHR and 95% CI adjusted for age, study center, SEER stage and genetic ancestry.
bInteraction P value for G × genetic ancestry interaction.