FIGURE 5.

A, shows the results of intestinal D-glucose infusion on jejunal SGLT1 expression, compared with water, in animals pretreated with capsaicin to de-afferent the vagus nerve. There is no significant difference in SGLT1 expression, either in terms of mRNA or lysate protein. B, examines the effects of pretreatment with ondansetron. The figure shows SGLT1 protein expression after infusion with D-glucose or water, in animals injected 30 minutes previously with ondansetron (1 mg/kg intraperitoneally; labeled “Ondansetron +”). This shows a blunted response compared with previous experiments without ondansetron pretreatment (labeled “Ondansetron −”; see Fig. 1A), reproduced alongside for comparison.